VP3.15 dihydrobromide
| CAS No. | 1281681-33-1 | Cat. No. | BCP31222 |
| Name | VP3.15 dihydrobromide | ||
| Synonyms | VP-3.15 dihydrobromide;VP3.15 2HBr;VP-3.15 2HBr; | ||
| Formula | C20H24Br2N4OS | M. Wt | 528.30 |
| Description | VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 dihydrobromide has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). | ||
| Pathways | Protease/Metabolic Enzyme Wnt/Stem Cell PI3K/Akt/mTOR | ||
| Targets | Phosphodiesterase/PDE GSK3 | ||
Structure
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