CBL 0137
CAS号 | 1197996-80-7 | 货号 | BCP29977 |
中文名 | CBL 0137 | ||
英文名 | CBL0137 | ||
中文别名 | |||
英文别名 | CBL-0137; CBL 0137; Curaxin 137; | ||
分子式 | C21H24N2O2 | 分子量 | 336.43 |
生物活性 | CBL0137, also known as Curaxin 137, is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 µM and inhibits NF-κB with an EC50 of 0.47 µM. CBL0137 inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma. CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. | ||
信号通路 | Apoptosis Pathway NFκB | ||
靶 点 | NF κB c Myc p53 |
结构式
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