PF-06273340
| CAS No. | 1402438-74-7 | Cat. No. | BCP29619 |
| Name | PF-06273340 | ||
| Synonyms | PF 06273340; PF06273340; PF-6273340; PF 6273340; PF6273340; | ||
| Formula | C23H22ClN7O3 | M. Wt | 479.92 |
| Description | PF-06273340 is a potent, selective, and peripherally restricted Pan-Trk Inhibitor with an excellent LipE profile (IC50 value: Trk-A = 6 nM; Trk-B = 4 nM; Trk-C = 3 nM). PF-06273340 has low metabolic turnover in HLM and hHep is a good substrate for efflux transporters P-gp (ER = 35.7) and BCRP (ER = 4.0) and has moderate passive permeability (RRCK Papp = 5.4 × 10−6 cm s−1). PF-06273340 is well-tolerated was selected as a candidate for clinical development. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Trk Receptor | ||
Structure
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