MK-0941 mesylate
CAS号 | 1137916-97-2 | 货号 | BCP25241 |
中文名 | MK-0941 mesylate | ||
英文名 | MK-0941 mesylate | ||
中文别名 | |||
英文别名 | MK-0941; MK 0941 mesylate; MK0941 mesylate; | ||
分子式 | C21H24N4O6S.CH4O3S | 分子量 | 556.61 |
生物活性 | MK-0941 mesylate (MK0941) is a novel potent, orally active Glucokinase (GK) activator with EC50 of 0.240 and 0.065 uM in 2.5 and 10 mM glucose, respectively; increases insulin secretion by 17-fold and glucose uptake up to 18-fold, respectively, in isolated rat islets of Langerhans and hepatocytes at 10 uM; exhibits strong glucose-lowering activity in rodent models of type 2 diabetes and healthy dogs. | ||
上下游产品 | 752240-01-0(MK-0941) | ||
信号通路 | Protease/Metabolic Enzyme | ||
靶 点 | Glucokinase |
结构式
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