Plecanatide
| CAS No. | 467426-54-6 | Cat. No. | BCP25087 |
| Name | Plecanatide | ||
| Synonyms | SP-304; SP 304; SP304; Trulance; | ||
| Formula | C65H104N18O26S4 | M. Wt | 1681.89 |
| Description | Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP). | ||
| Pathways | GPCR/G Protein | ||
| Targets | Guanylate Cyclase | ||
Structure
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