Halofuginone Hydrobromide
| CAS No. | 64924-67-0 | Cat. No. | BCP19376 |
| Name | Halofuginone Hydrobromide | ||
| Synonyms | Halofuginone HBr; Halofuginone-HBr; HalofuginoneHBr; | ||
| Formula | C16H18Br2ClN3O3 | M. Wt | 495.59 |
| Description | Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. | ||
| Pathways | TGF beta/Smad Wnt/Stem Cell | ||
| Targets | TGF β/Smad | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.