盐酸地拉普利
| CAS号 | 83435-67-0 | 货号 | BCP14202 |
| 中文名 | 盐酸地拉普利 | ||
| 英文名 | Delapril hydrochloride | ||
| 中文别名 | |||
| 英文别名 | Delapril HCl;CV-3317;CV 3317;CV3317; | ||
| 分子式 | C26H32N2O5.HCl | 分子量 | 489.01 |
| 生物活性 | Delapril Hydrochloride is the hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, delapril is converted to two active metabolites, delapril diacid and 5-hydroxy delapril diacid, which competitively bind to and inhibit ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Delapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. | ||
| 信号通路 | Protease/Metabolic Enzyme Hormone Pathay | ||
| 靶 点 | RAAS/ACE | ||
结构式
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