ZSTK474
  • 化学数据
CAS号 475110-96-4 货号 BCP01867
中文名 ZSTK474
英文名 ZSTK474
中文别名
英文别名 ZSTK-474;ZSTK 474;
分子式 C19H21F2N7O2 分子量 417.42
  • 用途
生物活性 ZSTK474 is a novel orally applicable phosphoinositide 3-kinase-specific inhibitor that strongly inhibits cancer cell proliferation. Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3β by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth.
信号通路 Wnt/Stem Cell PI3K/Akt/mTOR 
靶 点 GSK3 PI3K 

结构式

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