CUDC-101
CAS号 | 1012054-59-9 | 货号 | BCP01935 |
中文名 | CUDC-101 | ||
英文名 | CUDC-101 | ||
中文别名 | |||
英文别名 | CUDC101;CUDC 101; | ||
分子式 | C24H26N4O4 | 分子量 | 434.49 |
生物活性 | CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase Cell Cycle/DNA Damage Jak/Stat Pathway Epigenetics | ||
靶 点 | HDAC EGFR HER2 |
结构式
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