PIK75
| CAS No. | 945619-31-8 | Cat. No. | BCP27614 |
| Name | PIK75 | ||
| Synonyms | PIK-75;PIK 75; | ||
| Formula | C16H14BrN5O4S | M. Wt | 452.28 |
| Description | PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK-75, administered at 50 mg/kg, inhibited the growth of HeLa cell xenografts in mice models. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | DNA PK PI3K | ||
Structure
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