A-674563
CAS号 | 552325-73-2 | 货号 | BCP02557 |
中文名 | A-674563 | ||
英文名 | A-674563 | ||
中文别名 | |||
英文别名 | A 674563;A674563; | ||
分子式 | C22H22N4O | 分子量 | 358.44 |
生物活性 | A-674563 is achieved from A-443654 by replacing the indole with a phenyl moiety and getting oral activity. A-674563 slows proliferation of tumor cells with EC50 of 0.4 μM. [1] A-674563 does not inhibit Akt phosphorylation per se, but blocks the phosphorylation of Akt downstream targets in a dose-dependent manner. A-674563 induced Akt blockade results in decreased STS cell downstream target phosphorylation and tumor cell growth inhibiton. A-674563 induces G2 cell cycle arrest and apoptosis in STS cells. | ||
上下游产品 | A674563HCl(A674563 HCl) | ||
信号通路 | PI3K/Akt/mTOR | ||
靶 点 | AKT |
结构式
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