吡非尼酮
| CAS号 | 53179-13-8 | 货号 | BCP04473 |
| 中文名 | 吡非尼酮 | ||
| 英文名 | Pirfenidone | ||
| 中文别名 | 哌非尼酮;5-甲基-1-苯基-2-(1H)-吡啶酮; | ||
| 英文别名 | AMR69; AMR-69; AMR 69; | ||
| 分子式 | C12H11NO | 分子量 | 185.22 |
| 生物活性 | Pirfenidone is an anti-fibrotic drug for the treatment of idiopathic pulmonary fibrosis (IPF). It works by reducing lung fibrosis through downregulation of the production of growth factors and procollagens I and II. Pirfenidone has well-established antifibrotic and anti-inflammatory properties in various in vitro systems and animal models of fibrosis. A number of cell-based studies have shown that pirfenidone reduces fibroblast proliferation, inhibits TGF-β stimulated collagen production and reduces the production of fibrogenic mediators such as TGF-β. | ||
| 信号通路 | TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | TGF β/Smad | ||
结构式
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