多非利特
| CAS号 | 115256-11-6 | 货号 | BCP04770 |
| 中文名 | 多非利特 | ||
| 英文名 | Dofetilide | ||
| 中文别名 | |||
| 英文别名 | Tikosyn;UK-68798;UK 68789;UK68789; | ||
| 分子式 | C19H27N3O5S2 | 分子量 | 441.56 |
| 生物活性 | In patients with congestive heart failure and reduced left ventricular function, dofetilide was effective in converting atrial fibrillation, preventing its recurrence, and reducing the risk of hospitalization for worsening heart failure. Dofetilide had no effect on mortality. dofetilide preferentially blocks open (or activated) channels and that the fast inactivation may competitively slow the binding kinetics. Dofetilide acts as a slow-onset/slow-offset open channel blocker of this current at nanomolar concentrations . | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | Potassium Channel | ||
结构式
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