Tideglusib
CAS号 | 865854-05-3 | 货号 | BCP06016 |
中文名 | Tideglusib | ||
英文名 | Tideglusib | ||
中文别名 | |||
英文别名 | NP-12;NP031112;NP 031112;NP-031112; | ||
分子式 | C19H14N2O2S | 分子量 | 334.39 |
生物活性 | Tideglusib irreversibly inhibits GSK-3, reduces tau phosphorylation, and prevents apoptotic death in human neuroblastoma cells and murineprimary neurons.Tideglusib (2.5 μM) inhibits glutamate-induced glial activation as evidenced by decreased TNF-α and COX-2 expression in rat primary astrocyte or microglial cultures. Tideglusib (2.5 μM) also exerts a potent neuroprotective effect on cortical neurons from glutamate-induced excitotoxicity as evidenced by significant reduction in the number of Annexin-V-positive cells in rat primary astrocyte or microglial cultures. | ||
信号通路 | Wnt/Stem Cell PI3K/Akt/mTOR | ||
靶 点 | GSK3 |
结构式
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