TG 100572 Hydrochloride
CAS号 | 867331-64-4 | 货号 | BCP21364 |
中文名 | TG 100572 Hydrochloride | ||
英文名 | TG 100572 Hydrochloride | ||
中文别名 | |||
英文别名 | TG-100572; TG 100572; TG100572; TG-100572 HCl; | ||
分子式 | C26H27Cl2N5O2 | 分子量 | 512.43 |
生物活性 | TG-100572 is a potent and selective VEGFR2/Src kinase inhibitor. TG100572 inhibits Src kinases and selected receptor tyrosine kinases, induced apoptosis of proliferating endothelial cells in vitro. TG100572 inhibits downstream molecules involved in the vascular endothelial growth factor (VEGF) signaling pathway resulted in markedly diminished levels of HSV-induced angiogenesis and significantly reduced the severity of SK lesions. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Src/Bcr Abl VEGFR |
结构式
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