渥曼青霉素
| CAS号 | 19545-26-7 | 货号 | BCP07861 |
| 中文名 | 渥曼青霉素 | ||
| 英文名 | Wortmannin | ||
| 中文别名 | |||
| 英文别名 | SL2052; SL-2052; SL 2052;KY-12420;KY 12420;KY12420; | ||
| 分子式 | C23H24O8 | 分子量 | 428.43 |
| 生物活性 | Wortmannin, a steroid metabolite of the fungi Penicillium funiculosum, Talaromyces (Penicillium) wortmannii, is a specific, covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It has an in vitro inhibitory concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. Wortmannin has also been reported to inhibit members of the polo-like kinase family with IC50 in the same range as for PI3K. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | ATM/ATR DNA PK PI3K | ||
结构式
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