AZD-2932

  • 化学数据
CAS号 883986-34-3 货号 BCP07984
中文名 AZD-2932
英文名 AZD-2932
中文别名
英文别名 AZD2932;AZD 2932;
分子式 C24H25N5O4 分子量 447.49
  • 用途
生物活性 The same C6 in vivo model was used to study tumor growth inhibition (TGI) with AZD2932. Twice daily oral dosing (b.i.d.) 10 h apart resulted in significant TGI of 64% for both 50 and 12.5 mg/kg doses on the day the control animals were terminated (day 22 on the graph). Most importantly, xenografts bearing non-PDGFR expressing tumor cells were also sensitive to AZD2932 treatment: growth of Calu-6 tumor was inhibited by 81% and 72% at 50 and 12.5 mg/kg b.i.d. (p <0.001) and LoVo tumors by 67% at 50 mg/kg b.i.d. (p <0.001).
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 PDGFR VEGFR c Kit FLT3 

结构式

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