PF-04880594
CAS号 | 1111636-35-1 | 货号 | BCP21016 |
中文名 | PF-04880594 | ||
英文名 | PF-04880594 | ||
中文别名 | |||
英文别名 | PF04880594; PF 04880594; | ||
分子式 | C19H16F2N8 | 分子量 | 394.38 |
生物活性 | PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers. | ||
信号通路 | MAPK Pathway | ||
靶 点 | Raf |
结构式
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