JNJ-10198409
| CAS No. | 627518-40-5 | Cat. No. | BCP08276 |
| Name | JNJ-10198409 | ||
| Synonyms | JNJ 10198409;JNJ10198409; RWJ-540973; RWJ 540973; RWJ540973; | ||
| Formula | C18H16FN3O2 | M. Wt | 325.35 |
| Description | JNJ-10198409, also known as RWJ-540973, is an inhibitor of PDGF-BB tyrosine kinase with an IC50 value of 4.2 nM. JNJ-10198409 is a competitive antagonist of the ATP binding and hydrolysis at this receptor, resulting in a dose dependent inhibition of tumor growth and angiogenesis. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | PDGFR | ||
Structure
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