AU-15330
CAS号 | 2380274-50-8 | 货号 | BCP46987 |
中文名 | AU-15330 | ||
英文名 | AU-15330 | ||
中文别名 | |||
英文别名 | AU 15330; AU15330; | ||
分子式 | C39H49N9O5S | 分子量 | 755.94 |
生物活性 | AU-15330 is a novel, highly specific and VHL-dependent PROTAC degrader of SWI/SNF ATPase components (SMARCA2, SMARCA4 and PBRM1) that shows preferential cytotoxicity in enhancer-binding transcription factor-addicted cancers at low nanomolar concentrations. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide, even inducing disease remission in castration-resistant prostate cancer (CRPC) models without toxicity. | ||
信号通路 | Others Pathway Epigenetics | ||
靶 点 | Epigenetic Reader Domain PROTAC |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!