Asundexian
| CAS号 | 2064121-65-7 | 货号 | BCP46980 |
| 中文名 | Asundexian | ||
| 英文名 | Asundexian | ||
| 中文别名 | |||
| 英文别名 | BI1265162; BI-1265162; BI 1265162; BAY2433334; BAY 2433334; BAY-2433334; | ||
| 分子式 | C26H21ClF4N6O4 | 分子量 | 592.94 |
| 生物活性 | Asundexian, also known as BAY2433334 and BI1265162, is a blood coagulation factor XIa inhibitor. Asundexian binds directly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM. BAY 2433334 is a promising development candidate for once-daily oral anticoagulation; it is being evaluated in phase 2 dose-finding studies in patients at risk of thrombosis. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Factor Xa | ||
结构式
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