Tovinontrine
CAS号 | 2062661-53-2 | 货号 | BCP44778 |
中文名 | Tovinontrine | ||
英文名 | Tovinontrine | ||
中文别名 | |||
英文别名 | IMR-687; IMR 687; IMR687; | ||
分子式 | C21H26N6O2 | 分子量 | 394.47 |
生物活性 | Tovinontrine, also known as IMR-687, is a phosphodiesterase 9 (PDE9) inhibitor. IMR-687 increased cGMP and HbF in erythroid K562 and UT-7 cells and increased the percentage of HbF positive erythroid cells generated in vitro using a two-phase liquid culture of CD34+ progenitors from sickle cell blood or bone marrow. Oral daily dosing of IMR-687 in the Townes transgenic mouse SCD model, increased HbF and reduced red blood cell sickling, immune cell activation and microvascular stasis. | ||
信号通路 | Protease/Metabolic Enzyme | ||
靶 点 | Phosphodiesterase/PDE |
结构式
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