BAY8400
| CAS No. | BAY8400 | Cat. No. | BCP44636 |
| Name | BAY8400 | ||
| Synonyms | BAY-8400; BAY 8400; | ||
| Formula | C21H17F2N5O | M. Wt | 393.4 |
| Description | BAY-8400 is a novel selective inhibitor of DNA-PK. In in vitro studies, BAY-8400 showed synergistic activity of DNA-PK inhibition with DNA damage-inducing targeted alpha therapy. Combination of PSMA-targeted thorium-227 conjugate BAY 2315497 treatment of human prostate tumor-bearing mice with BAY-8400 oral treatment increased antitumor efficacy, as compared to PSMA-targeted thorium-227 conjugate monotherapy. | ||
| Pathways | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| Targets | DNA PK | ||
Structure
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