AZD-7451

  • 化学数据
CAS号 1079274-94-4 货号 BCP44112
中文名 AZD-7451
英文名 AZD-7451
中文别名
英文别名 AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092;
分子式 C18H19FN8O 分子量 382.39
  • 用途
生物活性 AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 Trk Receptor 

结构式

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