AZD-7451
CAS号 | 1079274-94-4 | 货号 | BCP44112 |
中文名 | AZD-7451 | ||
英文名 | AZD-7451 | ||
中文别名 | |||
英文别名 | AZD7451; AZD 7451; AZ12607092; AZ 12607092; AZ-12607092; | ||
分子式 | C18H19FN8O | 分子量 | 382.39 |
生物活性 | AZD7451 is a tropomyosin receptor kinase (TRK) inhibitor with potential antineoplastic activity. AZD7451 binds to TRK, thereby preventing the neurotrophin-TRK interaction and subsequent TRK activation. This may eventually result in an inhibition of tumor cell proliferation in TRK-expressing tumor cells. TRK, a receptor tyrosine kinase activated by neurotrophins, is mutated in a variety of cancer cell types and plays an important role in tumor cell growth, invasion and survival. | ||
信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
靶 点 | Trk Receptor |
结构式
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