EST64454 HCl
CAS号 | 1950569-11-5 | 货号 | BCP43797 |
中文名 | EST64454 HCl | ||
英文名 | EST64454 HCl | ||
中文别名 | |||
英文别名 | EST64454 hydrochloride;EST 64454 HCl;EST-64454 HCl; | ||
分子式 | C18H23ClF2N4O2 | 分子量 | 400.85 |
生物活性 | EST64454 is a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability in all species, linked to an adequate pharmacokinetic profile in rodents, and antinociceptive properties in the capsaicin and partial sciatic nerve ligation models in mice. | ||
信号通路 | GPCR/G Protein | ||
靶 点 | Sigma Receptor |
结构式
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