Bisindolylmaleimide VIII acetate
| CAS No. | 138516-31-1 | Cat. No. | BCP43574 |
| Name | Bisindolylmaleimide VIII acetate | ||
| Synonyms | Ro 31-7549 acetate; Bis VIII acetate;Bisindolylmaleimide VIII Acetic Acid Salt; | ||
| Formula | C24H22N4O2 | M. Wt | 398.46 |
| Description | Bisindolylmaleimide VIII acetate is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC. Bisindolylmaleimide VIII acetate has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively. Bisindolylmaleimide VIII acetate facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases. | ||
| Pathways | TGF beta/Smad Epigenetics | ||
| Targets | PKC | ||
Structure
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