EN4
| CAS号 | 1197824-15-9 | 货号 | BCP40015 |
| 中文名 | EN4 | ||
| 英文名 | EN4 | ||
| 中文别名 | |||
| 英文别名 | EN4 MYC inhibitor;EN-4; EN 4; | ||
| 分子式 | C25H24N2O4 | 分子量 | 416.47 |
| 生物活性 | EN4 is a functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. EN4 functionally and covalently targets an intrinsically disordered region in MYC. EN4 directly targets MYC in cells and reduces MYC and MAX thermal stability. EN4 inhibits MYC activity, downregulates MYC targets, and impairs tumorigenesis. MYC is a major oncogenic transcriptional driver of most human cancers that has remained intractable to direct targeting because much of MYC is intrinsically disordered. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | c Myc | ||
结构式
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