Silmitasertib sodium
| CAS号 | 1309357-15-0 | 货号 | BCP38774 |
| 中文名 | Silmitasertib sodium | ||
| 英文名 | Silmitasertib sodium | ||
| 中文别名 | |||
| 英文别名 | Silmitasertib sodium salt;CX-4945 sodium salt;CX4945 Sodium; | ||
| 分子式 | C19H11ClN3NaO2 | 分子量 | 371.75 |
| 生物活性 | Silmitasertib Sodium is the sodium salt of silmitasertib, an orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. CK2 regulates a diverse array of pro-survival cellular processes including epidermal growth factor receptor (EGFR) signaling, PI3K/AKT/mTOR signaling, hedgehog (Hh) signaling, Hsp90 machinery, hypoxia, and interleukin (IL)-6 expression. CK2 also regulates the activity of XRCC1 and MDC1, two mediator/adaptor proteins that are essential for DNA repair. | ||
| 信号通路 | Cell Cycle/DNA Damage Wnt/Stem Cell | ||
| 靶 点 | Casein Kinase | ||
结构式
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