西奥骨化醇

  • 化学数据
CAS号 134404-52-7 货号 BCP38354
中文名 西奥骨化醇
英文名 Seocalcitol
中文别名
英文别名 EB-1089;EB 1089;EB1089;
分子式 C30H46O3 分子量 454.68
  • 用途
生物活性 Seocalcitol is a vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.
信号通路 Others Pathway 
靶 点 Vitamin D Related 

结构式

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