Vebicorvir
  • 化学数据
CAS号 2090064-66-5 货号 BCP36939
中文名 Vebicorvir
英文名 Vebicorvir
中文别名
英文别名 ABI H0731; ABI-H0731; ABIH0731; ABIH 0731; ABIH-0731; ABI H 0731; ABI H-0731;
分子式 C19H12F3N3O4S2 分子量 467.44
  • 用途
生物活性 Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity. ABI-H0731 exhibited selective inhibition of HBV DNA replication (50% effective concentration [EC50] from 173 nM to 307 nM). Most importantly, ABI-H0731 suppressed covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM. Mechanism-of-action studies indicated that ABI-H0731 is a direct-acting antiviral that targets HBV core protein, preventing HBV pregenomic RNA (pgRNA) encapsidation and subsequent DNA replication.
信号通路 Microbiology/Virology 
靶 点 HBV 

结构式

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