SEN177
  • 化学数据
CAS号 2117405-13-5 货号 BCP33954
中文名 SEN177
英文名 SEN177
中文别名
英文别名 SEN 177;SEN-177;
分子式 C18H19FN6 分子量 338.38
  • 用途
生物活性 SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model.
信号通路 Neuro Signaling Pathway 
靶 点 Amyloid β 

结构式

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