PRI-724
CAS号 | 1422253-38-0 | 货号 | BCP32677 |
中文名 | PRI-724 | ||
英文名 | PRI-724 | ||
中文别名 | |||
英文别名 | PRI724; PRI 724; C-82 prodrug; ICG-001 analog; ICG001 analog; ICG 001 analog; | ||
分子式 | C33H35N6O7P | 分子量 | 658.65 |
生物活性 | PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. | ||
上下游产品 | 780757-88-2(ICG-001) 847591-62-2(ICG-001) | ||
信号通路 | Wnt/Stem Cell | ||
靶 点 | Wnt |
结构式
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