丁酸钠

  • 化学数据
CAS号 156-54-7 货号 BCP31813
中文名 丁酸钠
英文名 Sodium Butyrate
中文别名 正丁酸钠;
英文别名 Butyric acid sodium salt;
分子式 C4H7NaO2 分子量 110.09
  • 用途
生物活性 Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.
信号通路 Cell Cycle/DNA Damage Others Pathway 
靶 点 Autophagy HDAC 

结构式

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