Glumetinib

  • 化学数据
CAS号 1642581-63-2 货号 BCP31155
中文名 Glumetinib
英文名 Glumetinib
中文别名
英文别名 SCC244; SC-C244; SCC 244;
分子式 C21H17N9O2S 分子量 459.49
  • 用途
生物活性 Glumetinib is a novel, potent and highly selective inhibitor of c-Met in MET-dependent cancer models. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date. Moreover, this inhibitor profoundly and specifically inhibits c-Met signal transduction and thereby suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 c Met 

结构式

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