SAICAR

  • 化学数据
CAS号 3031-95-6 货号 BCP28964
中文名 SAICAR
英文名 SAICAR
中文别名
英文别名 Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate;
分子式 C13H19N4O12P 分子量 454.28
  • 用途
生物活性 SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation.

结构式

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