SAICAR
CAS号 | 3031-95-6 | 货号 | BCP28964 |
中文名 | SAICAR | ||
英文名 | SAICAR | ||
中文别名 | |||
英文别名 | Succino-AICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-5'-phosphate; | ||
分子式 | C13H19N4O12P | 分子量 | 454.28 |
生物活性 | SAICAR, also known as Succino-AICAR, is an intermediate in the de novo purine nucleotide synthesis pathway. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. SAICAR-mediated PKM2 protein kinase activity is necessary for EGF-induced cancer cell proliferation. |
结构式
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