Prima-1
CAS号 | 5608-24-2 | 货号 | BCP26191 |
中文名 | Prima-1 | ||
英文名 | Prima-1 | ||
中文别名 | 2,2-二(羟基甲基)-1-氮杂双环[2,2,2]辛烷-3-酮; | ||
英文别名 | 2,2-Bis(Hydroxymethyl)-3-Quinuclidinone; 2,2-Dimethylolquinuclidin-3-One; | ||
分子式 | C9H15NO3 | 分子量 | 185.22 |
生物活性 | PRIMA-1, named for p53 reactivation and induction of massive apoptosis, is an inhibitor of the growth of cell lines derived from various human tumor types in a mutant p53-dependent manner. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations. It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. | ||
信号通路 | Apoptosis Pathway Others Pathway | ||
靶 点 | Autophagy p53 |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!