BMS 777607
| CAS号 | 1196681-44-3 | 货号 | BCP13190 |
| 中文名 | BMS 777607 | ||
| 英文名 | BMS 777607 | ||
| 中文别名 | |||
| 英文别名 | BMS-777607;BMS777607; | ||
| 分子式 | C25H19ClF2N4O4 | 分子量 | 512.89 |
| 生物活性 | BMS 777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases. | ||
| 上下游产品 | 1025720-94-8（BMS-777607） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor | ||
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GAS6‐expressing and self‐sustaining cancer cells in 3D spheroids activate the PDK‐RSK‐mTOR pathway for survival and drug resistance
购于瀚香生物(Biochempartner)的BMS 777607(CAS:1196681-44-3)被引用 |
|
Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation
购于瀚香生物(Biochempartner)的BMS 777607(CAS:1196681-44-3)被引用 |
结构式
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