I-CBP112
| CAS No. | 1640282-31-0 | Cat. No. | BCP20774 |
| Name | I-CBP112 | ||
| Synonyms | |||
| Formula | C27H36N2O5 | M. Wt | 468.59 |
| Description | I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors CREBBP (CBP) and EP300 (IC50 = 0.142 and 0.625 μM, respectively). I-CBP112 has little activity against other bromodomains at concentrations up to 1 mM. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Acetyltransferase Epigenetic Reader Domain | ||
Structure
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