LY2922470
  • 化学数据
CAS号 1423018-12-5 货号 BCP24962
中文名 LY2922470
英文名 LY2922470
中文别名
英文别名 LY-2922470; LY 2922470;
分子式 C28H29NO4S 分子量 475.6
  • 用途
生物活性 LY2922470 is a Potent and Selective GPR40 Agonist for the Treatment of Type 2 Diabetes Mellitus. LY2922470 demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclinical testing. The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels.
信号通路 GPCR/G Protein 

结构式

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