常山酮氢溴酸盐
| CAS号 | 64924-67-0 | 货号 | BCP19376 |
| 中文名 | 常山酮氢溴酸盐 | ||
| 英文名 | Halofuginone Hydrobromide | ||
| 中文别名 | |||
| 英文别名 | Halofuginone HBr; Halofuginone-HBr; HalofuginoneHBr; | ||
| 分子式 | C16H18Br2ClN3O3 | 分子量 | 495.59 |
| 生物活性 | Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases. | ||
| 信号通路 | TGF beta/Smad Wnt/Stem Cell | ||
| 靶 点 | TGF β/Smad | ||
结构式
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