Remodelin hydrobromide

  • 化学数据
CAS号 1622921-15-6 货号 BCP19055
中文名 Remodelin hydrobromide
英文名 Remodelin hydrobromide
中文别名
英文别名
分子式 C15H15BrN4S 分子量 363.28
  • 用途
生物活性 Remodelin can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
信号通路 Epigenetics 
靶 点 Histone Acetyltransferase 

结构式

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