Glesatinib hydrochloride
| CAS号 | 1123838-51-6 | 货号 | BCP18872 |
| 中文名 | Glesatinib hydrochloride | ||
| 英文名 | Glesatinib hydrochloride | ||
| 中文别名 | |||
| 英文别名 | MGCD265 hydrochloride;MGCD 265 hydrochloride;MGCD-265 hydrochloride; | ||
| 分子式 | C31H27ClF2N5O3S2X | 分子量 | 655.16 |
| 生物活性 | Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered. Glesatinib, also known as MGCD-265, is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor c Met Tie2 | ||
结构式
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