Y 39983 dihydrochloride

  • 化学数据
CAS号 173897-44-4 货号 BCP18325
中文名 Y 39983 dihydrochloride
英文名 Y 39983 dihydrochloride
中文别名
英文别名 Y-39983 2HCl;Y-39983 dihydrochloride;Y39983 dihydrochloride;Y-33075; Y 33075; Y33075;
分子式 C16H18Cl2N4O 分子量 353.25
  • 用途
生物活性 Y-33075 dihydrochloride is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.Y-39983, also known as Y-33075, is a potent and selective inhibitor of ROCK family with IC50 value of 3.6nM for ROCK. Y-39983 attenuates experimental autoimmune encephalomyelitis via inhibition of demyelination. Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983, promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats.
信号通路 Cell Cycle/DNA Damage TGF beta/Smad  Wnt/Stem Cell 
靶 点 ROCK 

结构式

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