UNC2025

  • 化学数据
CAS号 1429881-91-3 货号 BCP16544
中文名 UNC2025
英文名 UNC2025
中文别名
英文别名 UNC-2025;UNC 2025;
分子式 C28H40N6O 分子量 476.66
  • 用途
生物活性 UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 TAM Receptor FLT3 

结构式

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