Kevetrin

  • 化学数据
CAS号 500863-50-3 货号 BCP28785
中文名 Kevetrin
英文名 Kevetrin
中文别名
英文别名 Thioureidobutyronitrile; Thioureido butyronitrile;
分子式 C5H9N3S 分子量 143.21
  • 用途
生物活性 Kevetrin ( thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. ).
信号通路 Apoptosis Pathway 
靶 点 p53 

结构式

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