Kevetrin
CAS号 | 500863-50-3 | 货号 | BCP28785 |
中文名 | Kevetrin | ||
英文名 | Kevetrin | ||
中文别名 | |||
英文别名 | Thioureidobutyronitrile; Thioureido butyronitrile; | ||
分子式 | C5H9N3S | 分子量 | 143.21 |
生物活性 | Kevetrin ( thioureidobutyronitrile), is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Upon intravenous administration, thioureidobutyronitrile activates p53 which in turn induces the expressions of p21 and PUMA (p53 up-regulated modulator of apoptosis), thereby inhibiting cancer cell growth and causing tumor cell apoptosis. Thioureidobutyronitrile may be effective in drug-resistant cancers with mutated p53. p53 tumor suppressor, a transcription factor regulating the expression of many stress response genes and mediating various anti-proliferative processes, is often mutated in cancer cells. ). | ||
信号通路 | Apoptosis Pathway | ||
靶 点 | p53 |
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服:
- 全国免费电话:400-099-8200
瀚香生物(Biochempartner) 的所有产品和服务仅用于科学研究,禁止用于人体和治疗!