双氯芬酸钾

  • 化学数据
CAS号 15307-81-0 货号 BCP13811
中文名 双氯芬酸钾
英文名 Diclofenac potassium
中文别名
英文别名
分子式 C14H10Cl2KNO2 分子量 334.24
  • 用途
生物活性 The primary mechanism of diclofenac responsible for its anti-inflammatory, antipyretic, and analgesic action is thought to be inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX). It also appears to exhibit bacteriostatic activity by inhibiting bacterial DNA synthesis. Inhibition of COX also decreases prostaglandins in the epithelium of the stomach, making it more sensitive to corrosion by gastric acid. This is also the main side effect of diclofenac. Diclofenac has a low to moderate preference to block the COX2-isoenzyme (approximately 10-fold) and is said to have, therefore, a somewhat lower incidence of gastrointestinal complaints than noted with indomethacin and aspirin.

结构式

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