度洛西汀
| CAS号 | 116539-59-4 | 货号 | BCP13463 |
| 中文名 | 度洛西汀 | ||
| 英文名 | Duloxetine | ||
| 中文别名 | |||
| 英文别名 | (S)-Duloxetine;LY248686;LY-248686;LY 248686; | ||
| 分子式 | C18H19NOS | 分子量 | 297.41 |
| 生物活性 | Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. Duloxetine is also considered a less potent inhibitor of dopamine reuptake. However, duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors and can therefore be considered to be a selective reuptake inhibitor at the 5-HT and NA transporters. Duloxetine undergoes extensive metabolism, but the major circulating metabolites do not contribute significantly to the pharmacologic activity. Major depressive disorder is believed to be due in part to an increase in pro-inflammatory cytokines within the central nervous system. Antidepressants including ones with a similar mechanism of action as duloxetine, i.e. serotonin metabolism inhibition, cause a decrease in proinflammatory cytokine activity and an increase in anti-inflammatory cytokines; this mechanism may apply to duloxetine in its effect on depression but research o | ||
| 上下游产品 | 136434-34-9（盐酸度洛西汀） 116817-11-9（(RS)-盐酸度洛西汀） 116539-60-7（R-(-)-度洛西汀） | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | SSRI | ||
结构式
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