瑞巴匹特

  • 化学数据
CAS号 111911-87-6 货号 BCP12128
中文名 瑞巴匹特
英文名 Rebamipide
中文别名
英文别名 OPC12759;OPC 12759;OPC-12759;Proamipide;
分子式 C19H15ClN2O4 分子量 370.79
  • 用途
生物活性 Rebamipide is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
信号通路 Neuro Signaling Pathway GPCR/G Protein 
靶 点 Prostaglandin Receptor COX 

结构式

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