VLX600
| CAS号 | 1622945-04-3 | 货号 | BCP10627 |
| 中文名 | VLX600 | ||
| 英文名 | VLX600 | ||
| 中文别名 | |||
| 英文别名 | VLX-600;VLX 600; | ||
| 分子式 | C17H15N7 | 分子量 | 317.14 |
| 生物活性 | VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells. It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs. It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice. | ||
| 信号通路 | Apoptosis Pathway Others Pathway | ||
| 靶 点 | Autophagy p53 | ||
结构式
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