NU 6027
| CAS号 | 220036-08-8 | 货号 | BCP09221 |
| 中文名 | NU 6027 | ||
| 英文名 | NU 6027 | ||
| 中文别名 | |||
| 英文别名 | NU-6027;NU6027; | ||
| 分子式 | C11H17N5O2 | 分子量 | 251.29 |
| 生物活性 | A cell-permeable, pyrimidine derivative that acts as an ATP-competitive CDK Inhibitor (Ki = 2.5 μM for CDK1, and Ki = 1.3 μM for CDK2), and demonstrates cytostatic properties among a panel of 57 cancer cell lines. Also inhibits ATR kinase (IC50 = 6.7 μM in MCF7 cells), but does not interfere with irradiation-induced autophosphorylation of DNA-PK or ATM. Potentiates a range of DNA-damaging cytotoxic drugs such as hydroxyurea (1.8-fold) and cisplatin (1.4-fold) at 10 μM, but not the anti-mitotic paclitaxel. Attenuates G2/M arrest following DNA damage and inhibits RAD51 focus formation. Shown to be synthetically lethal when DNA single-strand break repair is impaired in PARP-inhibited cells. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | ATM/ATR CDK | ||
结构式
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